purpose


Cynomolgus macaques from the Indian Ocean island of Mauritius have less genetic diversity than Asian rhesus or cynomolgus macaques. Reduced genetic diversity allows investigators to study animals with specific genetics, improve experimental reproducibility, and compare outcomes between animals with distinct genetics. As awareness of the unusual genetics of Mauritian macaques grows, researchers from academia and industry are designing creative studies impossible to replicate in other nonhuman primates.

We are pleased to announce a one-day research symposium that will bring together a community of researchers working with Mauritian macaques. The agenda will focus on:

• recent developments in Mauritian macaque genetics and genomics
• infectious disease, transplantation, and immunology research with Mauritian macaques
• opportunities and challenges of future Mauritian macaque research


agenda



8:00-8:15 a.m. Introduction in the H.F. DeLuca Forum
David O'Connor, Associate Director, Wisconsin National Primate Research Center

8:15-9:00 a.m. Steve Shipley, University of Maryland School of Medicine
"Gut Microbiota differences between Mauritian and non-Mauritian Cynomolgus macaques - differential responses to vaccination and pathogen challenge in a Shigella dysenteriae vaccine development study"

9:00-9:45 a.m. Jeffrey Rogers, Baylor College of Medicine
"History matters: Whole genome variability in Mauritian cynomolgus macaques"

9:45-10:15 a.m. Adam Ericsen, University of Wisconsin-Madison
"Identifying correlates of SIV control by whole genome sequencing of Mauritian cynomolgus macaques"

10:15-10:30 a.m. Coffee break

10:30-11:30 a.m. Roger LeGrand, Institute of emerging diseases and innovative therapy, Paris, France
"Vaccines and microbicides for prevention of SIV/SHIV mucosal transmission in Mauritian macaques"

11:30-12:15 p.m. Robert Burk, Albert Einstein College of Medicine
"Genital papillomaviruses and lesions in macaques"

12:15-1:00 p.m. Lunch (on your own) and poster setup
There are two restaurants within the Wisconsin Institutes for Discovery: Aldo's Cafe and Steenbock's On Orchard.

1:00-1:30 p.m. Poster session in the H.F. DeLuca Forum

1:30-2:15 p.m. Siew Ho, Bristol-Myers Squibb Inc.
"Application of RNA Interference Technology to Cynomolgus Models for Drug Discovery and Development"

2:15-3:00 p.m. Igor Slukvin, University of Wisconsin-Madison
"The value of limited MHC diversity in MCMs in developing preclinical models of stem cell therapies"

3:00-3:15 p.m. Coffee break

3:15-4:00 p.m. Hong Wu, Pfizer, Inc.
"Genetic Variability in Cynomolgus Monkeys and Its Application in Preclinical Toxicology Studies"

4:00-4:45 p.m. Tobias Heckel, Roche, Switzerland
"Pharmacogenomics in Cynomolgus monkeys for pre-clinical safety assessment"

4:45-5:30 p.m. Jonah Sacha, Oregon Health and Sciences University
"Leveraging the simplified genetics of Mauritian cynomolgus macaques to define novel Cytomegalovirus vector-induced T cell immunity"

5:30 p.m. Closing remarks

"What are the key opportunities and challenges to using Mauritian macaques for biomedical research?
• Dave O'Connor, University of Wisconsin-Madison
• Shelby O'Connor, University of Wisconsin-Madison

A mid-day poster session will allow attendees to showcase their research with Mauritian macaques. Participants interested in presenting a poster will be asked for an abstract at the time of registration.

registration



Click here to register.

For those interested in presenting a poster, abstract submission is integrated with the registration form.

The registration fee is $150 on or before March 15, 2014
After March 15, 2014, the registration fee is $200

The student registration fee is $75 on or before March 15, 2014
After March 15, 2014, the registration fee is $125
proof of student status is required

Discounted registrations are available for UW-Madison attendees who volunteer to assist with meeting logistics. Contact
Kristi Hall for more details.


travel


Madison, WI is a picturesque city that is the state capitol of Wisconsin and home to UW-Madison. It is renowned for its warm people, cultural offerings, and outdoor activities. The symposium will be held at the Wisconsin Institutes for Discovery, a new state-of-the-art research and conference facility.


The Dane County Regional Airport (MSN) is conveniently located on the east side of Madison, approximately 15 minutes by taxi from the UW-Madison campus. Alternately, many travelers prefer to fly into Chicago O'Hare (ORD) and take the three-hour ride on the Van Galder bus to Madison. Particularly for attendees connecting in Chicago, taking the Van Galder may be an economical and time-saving alternative to flying into Madison.


Several hotels are convenient to the Wisconsin Institutes for Discovery. In particular, we recommend:
Wisconsin Union Hotel (0.1m)
HotelRED (0.3 m)
Hilton Madison Monona Terrace (2.0m)
Arbor House, an Environmental Inn (3.0m)

Note that there is an excellent local bus system, making travel from most Madison-area hotels to the campus area convenient. Click here for assistance mapping transportation options from hotels to campus.


On-campus parking at UW-Madison is extremely limited. Please contact the organizers for suggestions if you require parking for the symposium.


scientific organizing committee


Dave O'Connor, UW-Madison
Shelby O'Connor, UW-Madison
Jonah Sacha, Oregon Health Sciences University

sponsors


We are profoundly grateful to the following sponsors:

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njabr
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If you are interested in contributing to this meeting as a donor or sponsor, please contact Kristi Hall.


contact


Please direct all administrative and logistic questions to Kristi Hall. Questions about the scientific content of the meeting should be sent to the conference chair Dave O'Connor.